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Advancements in cellular research have led to the explosion of interest for NAD+ and its precursors, particularly NMN (nicotinamide mononucleotide). Of great interest are the causes and effects of NAD+ depletion.
NAD+ levels are known to decrease not just from aging, but also from lifestyle choices. Physical inactivity, overconsumption, stress, and travel across time zones all negatively impact NAD+ levels in the body.In contrast, increases in NAD+ levels are experienced in response to intensive bouts of exercise or calorie restriction as well as when an NAD+ precursor is taken as a dietary supplement.With NMN being the immediate precursor to NAD+ in the cell, it is the subject of much research. Often mentioned in conversations discussing potential interventions to combat the effects of aging and cellular dysfunction, NMN has the potential to alter the way we age at the cellular level.Like many nutrients, NMN is available from various food sources, just not in the quantities needed to overcome the metabolic stressors actively depleting NAD+ levels. Preclinical studies have shown NMN, when delivered orally, can quickly (10-30 minutes after ingestion) and effectively increase levels of NAD+ across multiple tissues.
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